By N. W. F. Kossen (auth.), Enrique Galindo, Octavio T. Ramírez (eds.)
Bioprocess engineering performs a key position within the improvement and optimization of bioprocesses resulting in the goods of biotechnology. A survey of the state of the art during this box is drastically wanted. This paintings covers all of the crucial sub-areas and as such is needed analyzing for scientists lively in all of the disciplines desirous about bioprocess engineering. This evaluation of uncomplicated and utilized ways is introduced jointly through a large overseas team of professional authors.
The paintings is a mirrored image of the 1st foreign Symposium on Bioprocess Engineering, June 1994. although, it has to be emphasised that the e-book can't be perceived as a typical symposium complaints quantity: a strict peer-review approach assures the readers of a excessive point of caliber; greater than 1 / 4 of the paintings includes invited contributions, whereas under half the spontaneously submitted manuscripts have been accredited for ebook.
Advances in Bioprocess Engineering belongs one of the necessary set of tools of modern-day researcher during this box.
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Extra info for Advances in Bioprocess Engineering
It was this small scale process data that was to be used as the basis for design of thos new plant. PLANT AND PROCESS DESIGN The process used to produce anakinra is very straight forward (see Figure 1). The protein is produced by a recombinant strain of E. coli as a intracellular, soluble, active product. The cells are harvested using a disc stack The design and scale-up of each unit operation was approached in essectially the same way. An overall mass balance was written for the process as a whole by building it from 21 E.
5 with 2N NH 40H. 2 (adapted from [j1]). :I '" ~ 120 '" .. 200 ill 150 U 100 0 i:l Eo! Eo! > H 0 E! ~ :> 8I>: 60 E! ----..... o~--~~~~~--~--~ o 20 40 60 80 100 PARTICLE SIZE ( mesh ) Figure 7. E. coli strains on a whole cell biocatalyst activity. Wild strain: - . - 2 9 cell/g agar, - e- 8 9 cell/g agar. JM 102 strain: - 0- 2 9 cellig agar, - 0- 8 9 cell/g agar. for each reaction. It has also been shown that a minimum of batch cycles is required in order to minimize the influence of the biocatalyst cost in the 6-APA production costs.
44, 2402 (1989). LITERA'IURE CITED 1. Y. , Chern. Eng. , 60, 195 (1987). 2. Posarac, D. , Chern. Eng. , 43, 1161 (1988). 3. -J. , Chern. Eng. , 47, 2281 (1992). 9. , Tsujimura, M. , Bioprocess Eng. in print. 10. , Halard, B. , Chern. Eng. , 42, 1609 (1987). 4. F. recentl"! start-ul! of a new plant design~d to produce 1500 kg per year of anakinra, a human therapeutic protem. Anakmra IS a native human molecule that IS used by the body to control the activity of interleukin-1. nd then purified using a combination of standard unit operations.
Advances in Bioprocess Engineering by N. W. F. Kossen (auth.), Enrique Galindo, Octavio T. Ramírez (eds.)