By J.-L. Pierre (auth.), Prof. Dr. A. E. Favier, Prof. Dr. J. Cadet, Prof. Dr. B. Kalyanaraman, Prof. Dr. M. Fontecave, Prof. Dr. J.-L. Pierre (eds.)
"Oxidative tension" is used because the known time period describing the contain ment of reactive oxygen species in numerous human ailments. The scope of any such subject is turning into more and more broad. the hot curiosity in radicals reminiscent of nitric oxide and the invention of latest mechanisms equivalent to the influence of loose radicals on redox delicate proteins and genes are enlarging our figuring out of the physiological position of unfastened radicals. Oxidative pressure is occupied with quite a few pathological. techniques resembling growing older, respiration or cardiovascular illnesses, melanoma, neurological pathologies akin to dementia or Parkinson's ailment. It nonetheless is still tricky, even if, to illustrate via chemical dimension the in vivo construction of unfastened radicals or even extra to understand their speciation. for that reason, the advance of recent instruments and signs is engrossing many researchers operating during this box. trustworthy symptoms are abso lutely precious not just to observe the evolution of oxidative tension in sufferers but in addition to guage the potency of recent antioxidant deal with ments. The French unfastened radical membership of Grenoble, the CERLIB has been concerned for a few years within the organization of foreign education courses on method, so that it will offer either theoretical and functional aid to researchers from numerous nations. Such education classes were hugely profitable and contributors worth the oppor tunity to profit trustworthy thoughts. This confident echo explains why the researchers of CERLIB determined, with assistance from Prof. Dr. B. Kalyanaraman, to submit chosen concepts on unfastened radical re search.
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Extra resources for Analysis of Free Radicals in Biological Systems
51. W. A. (1994) Agonist-induced peroxynitrite production from endothelial cells. Arch. Biochem. Biophys. 310: 352-359. 52. S. The double-edged role of nitric oxide in brain function and superoxidemediated injury. J. Dev. Physiol. IS: 53-59. 53. , Graham, A. and Moncada, S. (1993) Peroxynitrite and atherosclerosis. Biochemical Society Transactions 21: 358-362. 54. A. and Tarpey, M. (1994). Superoxide, and peroxynitrite in atherosclerosis. Proc. Natl. A cad. Sci. USA 91: 1044-1048. Pro-oxidant and antioxidant effects of nitric oxide 49 55.
After initiation by an external oxidant, the propagation of lipid peroxidation occurs by reactions 9 and 10, where LH represents an unsaturated lipid; V, a V+02~LOO' LOO'+LH~LOOH+L' (9) (10) Pro-oxidant and antioxidant effects of nitric oxide 45 lipid radical; LOO·, a lipid peroxyl radical and LOOH, a lipid hydroperoxide. The net result of this process is the conversion of lipid into lipid hydroperoxide. The central role of the peroxyl radical in this process can be gleaned from Equations (9) and (10) and compounds that scavenge lipid peroxyl radicals, such as butylated hydroxy toluene and probucol, are potent inhibitors of lipid peroxidation.
1993) Peroxynitrite-induced liminol chemiluminescence. Biochem. J. 290: 51- 57. 56. , Hegi, U. and Sies, H. (1993) Loss of x-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-I. FEBS Lett. 315: 139-142. 57. , Ischiropoulos, H. S. (1993) Peroxynitritemediated oxidation of dihydrorhodamine 123. Free Rad. Bioi. Med. 16: 149-156. 58. Jessup, W. T. (1993) Autoinhibition of murine macrophage-mediated oxidation of low-density lipoprotein by nitric oxide. Atherosclerosis 101: 145-155. 59.
Analysis of Free Radicals in Biological Systems by J.-L. Pierre (auth.), Prof. Dr. A. E. Favier, Prof. Dr. J. Cadet, Prof. Dr. B. Kalyanaraman, Prof. Dr. M. Fontecave, Prof. Dr. J.-L. Pierre (eds.)