Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant PDF

Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant PDF

By David A. Gewirtz, Shawn E. Holt, Steven Grant

ISBN-10: 1588295273

ISBN-13: 9781588295279

This booklet offers perception into proven practices and learn into apoptosis and senescence. the quantity completely examines novel and rising suggestions and learn within the fields of telephone demise pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different subject matters that also carry mysteries for researchers. In overall, this quantity offers simple scientists and clinicians with a deeper and extra whole knowing of the mobile responses of malignancies that can confirm the effectiveness of therapy, either within the preliminary levels of the illness in addition to in sickness recurrence.

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Additional info for Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

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95. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94:491–501. 96. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome C release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94(4):481–90. 97. Barry M, Heibein JA, Pinkoski MJ, et al. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

288. Youle RJ. Cell Biology. Cellular demolition and the rules of engagement. Science 2007; 315:776–7. 289. Riedl SJ, Salvesen, GF. The apoptosome: signalling platform of cell death. Nature Rev Mol Cell Biol 2007; 8:405–13. 2 The Extrinsic Pathway of Apoptosis M. Stacey Ricci, ScD, and Wafik S. El-Deiry, MD, PhD Summary Defects in the extrinsic pathway are linked to several disease states, including cancer. Pharmacologic manipulation of the extrinsic pathway holds exciting promise for cancer treatment.

Domina AM, Smith JH, Craig RW. Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition. J Biol Chem 2000; 275:21688–94. 135. Meng X, Chandra J, Loegering D, et al. Central role of FADD in apoptosis induction by the mitogen activated protein kinase kinase inhibitor CI1040 (PD184352) in acute lymphocytic leukemia cell lines in vitro. J Biol Chem 2003; 278:47236–339.

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Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development) by David A. Gewirtz, Shawn E. Holt, Steven Grant


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