By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
The recent box of toxicogenomics offers a possibly robust set of instruments to raised comprehend the well-being results of exposures to toxicants within the setting. on the request of the nationwide Institute of Environmental healthiness Sciences, the nationwide learn Council assembled a committee to spot some great benefits of toxicogenomics, the demanding situations to attaining them, and power techniques to overcoming such demanding situations. The document concludes that knowing the possibility of toxicogenomics to enhance public healthiness judgements would require a concerted attempt to generate info, utilize current information, and learn facts in new ways--an attempt requiring investment, interagency coordination, and knowledge administration suggestions.
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Extra info for Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
2006) developed a rapid method for analyzing the methylation status of hundreds of preselected genes simultaneously through an adaptation of a genotyping assay. For example, the methylation state of 1536 specific CpG sites in 371 genes was measured in a single reaction by multiplexed genotyping of bisulfite-treated genomic DNA. The efficient nature of this quantitative assay could be useful for DNA methylation studies in large epidemiologic samples. Hayashi et al. (2007) describe a method for analysis of DNA methylation using oligonucleotide microarrays that involves separating methylated DNA immunoprecipitated with anti-methylcytosine antibodies.
To move toward this goal, it is important to improve the quantity and quality of data available for deriving screening profiles and to develop a database to organize this information. The process of creating such a database could be accelerated by addressing proprietary and legal hurdles so at least some of the toxicogenomic data currently in private databases could be made available, and by integrating toxicogenomic assays into ongoing chemical screening and testing initiatives such as those conducted by the National Toxicology Program.
Two-color arrays involve fluorescently labeling paired samples (control versus experimental) with different dyes (see Figure 2-3). The amplified, labeled sequences, termed “targets,” are then hybridized to the microarrays. After hybridization and washing, the arrays are imaged with a confocal laser scanner and the relative fluorescence intensity (or streptavidin-conjugated phycoerythrin) for each gene-specific probe represents the expression level for that gene. The actual value reported depends on the microarray technology platform used and the experimental design.
Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology